dni

DNI-Glutamate ((S)-α-Amino-2,3-dihydro-4-methoxy-5,7-dinitro-δ-oxo-1H-indole-1-pentanoic acid) is a caged form of the glutamate neurotransmitter, which is photocleavable by one- (lexc = 360 nm) as well as two-photon irradiation (lexc = 720 nm). Upon photocleaveage, the bioactive glutamate is released instantly and behaves as a neurotransmitter, which provides information about receptor distribution, channel kinetics and network circuitry of the neuronal network. DNI-Glu is an analogue of the common MNI-Glu compound, but it exhibits cca. 7-10 times larger efficiency in terms of quantum yields compared to the MNI compound. DNI-Glu has low biotoxicity and high water-solubility as well (at physiologic pH). Due to these properties, currently DNI-Glu is thought to be the most advanced caged-glutamate compound for neuroscientific research.

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