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"Rx (Medicate)" is a song performed by Canadian rock band Theory of a Deadman, a track on their sixth studio album, Wake Up Call (2017). The song's lyrics were co-written by all four members of the band and address the prescription drug abuse epidemic occurring in North America. It was produced by Martin Terefe and recorded at Terefe's Kensaltown Studios in London. Along with the group's usual hard rock sound, the song uses elements of pop and country music genres. The band's transition into the pop genre has been associated with lead singer Tyler Connolly's newly acquired piano-playing ability, which forced a change in his songwriting style.
"Rx (Medicate)" was released alongside its music video on July 27, 2017, as the lead single from Wake Up Call and served as an instant download on pre-orders of the album. It received mixed reviews from music critics and was praised for being socially aware but criticized for aspects of its music and lyrics. The single became Theory of a Deadman's third single to top the Billboard U.S. Mainstream Rock chart, and was certified 4x platinum by Music Canada and 3x platinum by the Recording Industry Association of America. It earned the band a No. 1 Song Award from the Society of Composers, Authors and Music Publishers of Canada (SOCAN) and was nominated for "Rock Song of the Year" at the 2018 iHeartRadio Music Awards.
Theory of a Deadman partnered with Shatterproof, a nonprofit organization focused on education about alcohol and drug dependence, helping addicts' families, and reducing the stigma associated with drug abuse. At live concerts, the band encourage their audience to seek help if they are battling addiction and invite their fans to share their personal stories. They also sell lapel pins bearing the song's title to benefit Shatterproof at their concerts.

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